| 32 | Laura Haley/Shannon Sertz (WOO) def. Erin LaBarge/Mary DeVries (HOPE) 8-3 |
| 32 | Sydney Bergman/Makayla Sutter (OTT) def. Maja Shaw Todorovic/Rainie Heck (OBEW) 8-3 |
| 32 | Maddie Minaudo/Elizabeth Preister (SMC) def. Jennifer Stroyne/Carlye Campagna (JCU-W) 8-4 |
| 32 | Ashtyn Morris/Becca Liebler (BW-W) def. Morgan Arroyo/Natalie Overby (DENW) 8-3 |
| 32 | Nina Cepeda/Mira Amin (CWR-W) def. Natalie Bourlas/Nicolette Bourlas (JCU-W) 9-8 (7-1) |
| 32 | Navarro, Estefania/Travis, Adrienne (UCW) def. Olivia Conover/Lauren Solano (ALBW) 8-1 |
| 32 | Allison Watts/Tyranny Miller (LFC) def. Behrle, Monica/Watts, Madison (WUWT) 8-4 |
| 32 | Leah Newhof/Madeline Brouwer (CALVIN) def. Angell, Molly/Donovan, Melissa (MILLIKIN) 8-2 |
| 32 | Maria Franco/Laura Hanselman (KZOO-W) def. Sabine Worthoff/Mackenzie Wills (ONU) 8-3 |
| 32 | Imani Robinson/Jayde Robinson (BW-W) def. Sophia Navas-Davis/Emily Quill (OTT) 8-4 |
| 32 | Timm, Annie/Badawi, Zeana (AUGIE) def. Mayada Audeh/Jackie McDermott (OBEW) 8-6 |
| 32 | Megan Davy/Monica Davy (SMC) def. Lauren Beier/Katrin Gurvich (CWR-W) 8-6 |
| 32 | Libby Grant/Grace Haigh (DPUW) def. Alex Oswalt/Bella Russo (KZOO-W) 8-6 |
| 32 | Leeza Bodnar/Julie Lord (LFC) def. Katie Curry/Ola Latala (ONU) 8-1 |
| 32 | Colbert, Morgan/Halicka, Weronika (IITWOMEN) def. Wheeler, Kathryn/Gaudio, Chiara (ELMHURST) 8-3 |
| 32 | Joy Li/Morgan Wagers (WOO) def. Vilde Olvin/Juvel Vinluan (NPUW) 8-6 |
| 16 | Sydney Bergman/Makayla Sutter (OTT) def. Laura Haley/Shannon Sertz (WOO) 8-2 |
| 16 | Maddie Minaudo/Elizabeth Preister (SMC) def. Becca Liebler/Ashtyn Morris (BW-W) 8-2 |
| 16 | Nina Cepeda/Mira Amin (CWR-W) def. Navarro, Estefania/Travis, Adrienne (UCW) 8-6 |
| 16 | Leah Newhof/Madeline Brouwer (CALVIN) def. Allison Watts/Tyranny Miller (LFC) 8-2 |
| 16 | Maria Franco/Laura Hanselman (KZOO-W) def. Imani Robinson/Jayde Robinson (BW-W) 8-3 |
| 16 | Timm, Annie/Badawi, Zeana (AUGIE) def. Megan Davy/Monica Davy (SMC) 8-3 |
| 16 | Leeza Bodnar/Julie Lord (LFC) def. Grace Haigh/Libby Grant (DPUW) 8-1 |
| 16 | Halicka, Weronika/Colbert, Morgan (IITWOMEN) def. Joy Li/Morgan Wagers (WOO) 8-3 |
| QF | Sydney Bergman/Makayla Sutter (OTT) def. Maddie Minaudo/Elizabeth Preister (SMC) 8-6 |
| QF | Nina Cepeda/Mira Amin (CWR-W) def. Leah Newhof/Madeline Brouwer (CALVIN) 8-3 |
| QF | Laura Hanselman/Maria Franco (KZOO-W) def. Timm, Annie/Badawi, Zeana (AUGIE) 8-5 |
| QF | Halicka, Weronika/Colbert, Morgan (IITWOMEN) def. Leeza Bodnar/Julie Lord (LFC) 8-1 |
| SF | Nina Cepeda/Mira Amin (CWR-W) def. Sydney Bergman/Makayla Sutter (OTT) 8-2 |
| SF | Colbert, Morgan/Halicka, Weronika (IITWOMEN) def. Maria Franco/Laura Hanselman (KZOO-W) 8-5 |
| CH | Colbert, Morgan/Halicka, Weronika (IITWOMEN) def. Nina Cepeda/Mira Amin (CWR-W) 8-1 |
